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About TFDF

TFDF™ (Tangential Flow Depth Filtration) unites the benefits of TFF and depth filtration in a closed and single-use device.

Breakthrough technology redefines classic clarification***

Breakthrough technology for bioprocessing clarification

Combining the power of tangential flow and depth filtration

Tangential Flow

High cell density

High product retention

Depth Filtration

Low product retention

Low cell density

Tangential Flow Depth Filtration

High cell density

Low product retention

Tubular Depth Filter Operated in Tangential Flow Mode

Tangential flow through the lumen

  • Low concentration polarization
  • Robustness towards challenging feed stocks

Thick wall depth filter

  • High filtration capacity
  • Short, highly interconnected paths create low retention factor

Synergistic Benefits

  • Low volume sterilization
  • Small footprint.  Simple disposal
  • Multi-harvest and perfusion applications
  • Scalable from 1-2000L
  • Fast processing time typically < 8 hours

Filter, flow path and system as one solution

Filter

tubular TFDF™ filter scales from 1-2000L
 

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See how it works

Flow Path

closed, gamma-irradiated, customizable  complete with sensors

flowpath.png

See how it works

System

automated process control logic scales from lab to process

Lab-Scale-System-Angled_For-DataSheet.png

See How it works

Repligen-Guided Implementation Ensures Success

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HOW IT WORKS

VIDEOS TO BE ADDED

Proven performance in rProtein Clarification

Accordions:

  1. Robust CHO Harvest with 99% Yield (Slide 13, 14)
  2. Excellent Scaling Performance
  3. Repeatable Across Filters (Same Feed)
  4. Reliable Throughput Saves Time and Space